Minoxidil and dexamethasone eluting nanofiber dressing for cutaneous wound healing in rat

Background: Minoxidil is an antihypertensive agent and vasodilator which may help to promote local blood flow thus hastening the closure of excisional skin wounds. Corticosteroids down-regulate wound healing. This work aims develop characterize nanofiber-eluting dexamethasone minoxidil investigate their effect on healing in a rat model. Methods: dexamethasone-loaded dressings were developed characterized with scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FT-IR). In vitro, drug release studies performed for 12 days. To model wound-healing activity formulations, wounds created dorsal section male rats. Results: All electrospun dressing nanofibers displayed smooth structures surfaces without crystals. Histological results Hematoxylin & Eosin Masson’s trichrome staining indicate suppression dexamethasone-treated group good minoxidil-treated group. Here we identified that application topical can be effective probably driven by anagen hair growth while suppresses collagen production prevents scar formation. Conclusion: The findings suggest this potentially as new treatment modality clinic accelerate preventing